• Home
  • About Us
    • Member Directory
    • Contact Us
  • Blogs
    • Scientific Blogs
      • Technology
      • Environment
      • Health
    • Infinity Explorer
    • Traveler Book
    • Life Around
  • Publication
  • Scientific Advisory
  • Project
    • Future Projects
    • Ongoing Projects
    • Previous Projects
  • Services
    • Language Programs
    • Latest Software
    • Environmental Consultancy
    • Internship
    • Exercise
  • Career
    • Masters
    • PHDs
    • Postdoctorals
    • Travel Grants
    • Others

Infrared imaging to measure glymphatic function

Infrared imaging to measure glymphatic function

glymphatic function

Share:

Twitter
Tweet
LinkedIn
Share
Facebook
fb-share-icon
WeChat
Follow by Email
Hardin Bitsky

Hardin Bitsky

Mr. Hardin, a future doctor of pharmacy, provides services as a content writer for scientific and technical niches.

The glymphatic system facilitates fluid exchange in the central nervous system and clears dissolved wastes. This anatomically organized movement occurs primarily during sleep and is supported by astroglial neural cells via water channels called aquaporins. These channels line the perivascular pathways and facilitate cerebrospinal fluid and interstitial fluid exchange throughout the brain.

Glymphatic dysfunction has been implicated in numerous pathological conditions, including Alzheimer’s disease, traumatic brain injury, and stroke. Existing methods for assessing glymphatic function have been challenging. Dynamic methods such as 2-photon microscopy and contrast-enhanced magnetic resonance imaging (MRI) require expensive instrumentation and specific technical skills, yet they have other limitations. For instance, 2-photon microscopy cannot reliably access deeper brain regions. The more readily implemented and widely used method of slice-based fluorescent imaging permits assessment at only a snapshot of a single time point, so obtaining a view across time requires many animals and much effort.

To address the need for combined dynamic imaging and histologic assessment in glymphatic research, a team of researchers at the US Department of Veterans Affairs (VA) Puget Sound Health Care System and the University of Washington (UW) in Seattle recently developed a straightforward and novel dynamic imaging paradigm as a surrogate measure of glymphatic flux within the brain. As reported in Neurophotonics, the technique uses a widely available small animal infrared (IR) imaging system (LICOR Pearl) to obtain a sensitive dynamic surrogate measure of glymphatic exchange. It does so by tracking the distribution of an IR tracer in cerebrospinal fluid in real time over the cortical surface of a living mouse brain.

The technique enables measurement of the temporal dynamics of glymphatic functions, as well as the ability to follow up with the gold standard slice-based fluorescence analysis and histological evaluation for concurrent visualization of resolution of deeper structures. This approach allows both dynamic and structural insights to be assessed in parallel. The technique works great for research involving mice, but not for larger animals like rats, due to the size of the imaging platform and the thicker skulls of larger rodents.

The team’s reliance on affordable and widely available equipment readily allows for replication and widespread adoption. According to the study senior author Jeffrey Iliff, Associate Director for Research at the VISN20 Mental Illness, Research, Education, and Clinical Center of the VA Puget Sound Health Care System and the Arthur J. and Marcella McCaffray Professor in Alzheimer’s Disease at the UW School of Medicine, “The glymphatic field is expanding rapidly, both in the clinical and pre-clinical realms. With so much work to do, we hope that this simple, low-cost approach will place rigorous study of glymphatic biology within the reach of a wider, more diverse group of research teams and institutions.”

You may like to read:

‘Friendly’ gut bacteria may eliminate pathogens by competing for energy resources

Hepatitis Outbreak In Children: Explainer On Adenovirus Type 41, The Possible Culprit

PrevPreviousmRNA vaccines like Pfizer and Moderna fare better against COVID-19 variants of concern
NextScientists see signs of traumatic brain injury in headbutting muskoxNext

LATEST Blogs

Breakfast and health problems

Skipping Breakfast May Increase a Child’s Risk of Psychosocial Health Problems

September 7, 2022
James webb telescope

NASA’s Webb Space Telescope Captures a Cosmic Tarantula

September 7, 2022

Worse Than Smoking – Bad Sleep Can Worsen Lung Disease

August 31, 2022
Nanotechnology

Dr. Muhammad Adeel Addressed the International Con-ference as keynote speaker

August 23, 2022
Benefits of Mushrooms

Top 10 Health Benefits of Mushrooms, the Ultimate Superfood

August 18, 2022

New Way Invented To Produce Oxygen on Mars for Future Explorers

August 18, 2022

Evidence of Unprecedented Modern Sea-Level Rise Found in Ancient Caves

August 18, 2022

Research Shows Salt Substitutes Lower Risk of Heart Attack/Stroke and Death

August 13, 2022
covid symptoms

Hair Loss and Sexual Dysfunction Join Fatigue and Brain Fog in List of Long COVID Symptoms

August 13, 2022
protein

Most People Are Eating Too Much Protein – And It Has Serious Consequences

August 13, 2022

Categories

  • Scientific Blogs
  • Infinity Explorer
  • Traveler Book
  • Life Around

If you have tried to make a difference and you believe you deserve to be acknowledge, then please submit your story to us

Subscribe

Virtual Green Innovation Hub (VGI-H) is an emerging platform for young researchers which works as a bridge between You and the society.

Useful Links

Home
About us
Blogs

Subscribe Now

Don’t miss our future updates! Get Subscribed Today!

Copyright ©2022 Virtual Green Innovation Hub. All Rights Reserved.

Don’t miss our future updates. Get Subscribed Today!